Altered Patterns of Dynorphin lmmunoreactivity Suggest Reorganization in Human Hippocampal Epilepsy Mossy Fiber
نویسندگان
چکیده
‘California Comprehensive Epilepsy Program and Southwest Regional Epilepsy Center, Neurology and Research Services, Veterans Administration Medical Center, West Los Angeles, Wadsworth Division, Los Angeles, California 90073, Departments of *Anatomy and 3Neurology and 4Brain Research Institute, University of California School of Medicine, Los Angeles, California 90024, and 5 Department of Surgery/Neurosurgery, Santa Monica Hospital, Santa Monica, California 90404
منابع مشابه
Pii: S0306-4522(99)00249-3
The endogenous k receptor selective opioid peptide dynorphin has been shown to inhibit glutamate receptor-mediated neurotransmission and voltage-dependent Ca21 channels. It is thought that dynorphin can be released from hippocampal dentate granule cells in an activity-dependent manner. Since actions of dynorphin may be important in limiting excitability in human epilepsy, we have investigated i...
متن کاملSeizures induce dramatic and distinctly different changes in enkephalin, dynorphin, and CCK immunoreactivities in mouse hippocampal mossy fibers.
Light microscopic immunocytochemical techniques were used to evaluate the influence of recurrent limbic seizure activity on the immunoreactivity for 3 neuropeptides--enkephalin, dynorphin, and cholecystokinin (CCK)--contained within the mouse hippocampal mossy fiber axonal system. Seizures were induced either by the placement of a small unilateral electrolytic lesion in the dentate gyrus hilus ...
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Neural firing patterns are an essential determinant of normal axon terminal growth and synaptic connectivity in developing afferent pathways, but the trophic role of synchronous activity in associative neural networks is less well defined. We examined the ontogeny of inherited synchronous hippocampal network discharges and mossy fiber innervation patterns at sequential stages of development in ...
متن کاملInhibition of dentate granule cell neurogenesis with brain irradiation does not prevent seizure-induced mossy fiber synaptic reorganization in the rat.
Aberrant reorganization of dentate granule cell axons, the mossy fibers, occurs in human temporal lobe epilepsy and rodent epilepsy models. Whether this plasticity results from the remodeling of preexisting mossy fibers or instead reflects an abnormality of developing dentate granule cells is unknown. Because these neurons continue to be generated in the adult rodent and their production increa...
متن کاملSingle mossy fiber axonal systems of human dentate granule cells studied in hippocampal slices from patients with temporal lobe epilepsy.
Previous histological and immunocytochemical studies suggest that reorganization of the dentate granule cell axons, the mossy fibers, can occur in epileptic human hippocampus (Sutula et al., 1989; Houser et al., 1990; Babb et al., 1991) and in animal models of epilepsy (Tauck and Nadler, 1985; Sutula et al., 1988; Cronin et al., 1992). However, neuroanatomical analyses of the trajectory and mor...
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تاریخ انتشار 2003